Assessing the Presence of Recent Adaptation in the Human Genome With Mixture Density Regression.

ABSTRACT: How much genome differences between species reflect neutral or adaptive evolution is a central question in evolutionary genomics. In humans and other mammals, the presence of adaptive versus neutral genomic evolution has proven particularly difficult to quantify. The difficulty notably stems from the highly heterogeneous organization of mammalian genomes at multiple levels (functional sequence density, recombination, etc.) which complicates the interpretation and distinction of adaptive versus neutral evolution signals. In this study, we introduce mixture density regressions (MDRs) for the study of the determinants of recent adaptation in the human genome. MDRs provide a flexible regression model based on multiple Gaussian distributions. We use MDRs to model the association between recent

SUBMITTER: Salazar-Tortosa DF 

PROVIDER: S-EPMC10563788 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature