Ohnologs and SSD Paralogs Differ in Genomic and Expression Features Related to Dosage Constraints.

ABSTRACT: Gene duplication is recognized as a critical process in genome evolution; however, many questions about this process remain unanswered. Although gene duplicability has been observed to differ by duplication mechanism and evolutionary rate, there is so far no broad characterization of its determinants. Many features correlate with this difference in duplicability; however, our ability to exploit these observations to advance our understanding of the role of duplication in evolution is hampered by limitations within existing work. In particular, the existence of methodological differences across studies impedes meaningful comparison. Here, we use consistent definitions of duplicability in the human lineage to explore these associations, allow resolution of the impact of confounding factors,

SUBMITTER: Vance Z 

PROVIDER: S-EPMC10563793 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature