Transcriptional Response of Burkholderia cenocepacia H111 to Severe Zinc Starvation.

ABSTRACT: Burkholderia cenocepacia is an opportunistic pathogen that is primarily associated with severe respiratory infections in people with cystic fibrosis. These bacteria have significant intrinsic resistance to antimicrobial therapy, and there is a need for more effective treatments. Bacterial zinc uptake and homeostasis systems are attractive targets for new drugs, yet our understanding of how bacteria acquire and utilise zinc remains incomplete. Here we have used RNA-sequencing and differential gene expression analysis to investigate how B. cenocepacia H111 is able to survive in zinc poor environments, such as those expected to be encountered within the host. The data shows that 201 genes are significantly differentially expressed when zinc supply is severely limited. Included i

SUBMITTER: Barnett JP 

PROVIDER: S-EPMC10563805 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature