The Use of CD200 in the Differential Diagnosis of B-Cell Lymphoproliferative Disorders.

ABSTRACT: Background: B-Cell Lymphoproliferative Disorders (B-LPDs) are a group of heterogenous disorders characterised by the accumulation of B-cells in peripheral blood, bone marrow, lymph nodes and spleen. They have a variable disease course and outcome and many share similar features making differential diagnosis challenging. Therefore, accurate diagnosis is fundamental in particular for determining treatment options. Immunophenotyping by flow cytometry plays a crucial role in the diagnosis of B-LPDs. However, overlapping immunophenotyping patterns exist and the use of novel monoclonal antibodies has become increasingly important in immunophenotyping analysis. More recently differential expression of CD200 has been reported in various B-LPDs and that CD200 may improve the differentiation

SUBMITTER: Al-Zubaidi HK 

PROVIDER: S-EPMC10563807 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature