Epigenome-wide association studies of allergic disease and the environment.

ABSTRACT: The epigenome is at the intersection of the environment, genotype, and cellular response. DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been systematically evaluated in human studies by using untargeted epigenome-wide association studies (EWASs) and shown to be both sensitive to environmental exposures and associated with allergic diseases. In this narrative review, we summarize findings from key EWASs previously conducted on this topic; interpret results from recent studies; and discuss the strengths, challenges, and opportunities regarding epigenetics research on the environment-allergy relationship. The majority of these EWASs have systematically investigated select environmental exposures during the prenatal and early childhood periods and aller

SUBMITTER: Cardenas A 

PROVIDER: S-EPMC10564109 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature