Therapeutic dosing and targeting efficacy of Pt-Mal-LHRH towards triple negative breast cancer.

ABSTRACT:

Objective

Pt-Mal-LHRH is a newly synthesized chemotherapeutic agent that was designed to selectively target the luteinizing hormone-releasing hormone (LHRH) receptor expressed by triple negative breast cancer (TNBC). The aim of this study was to evaluate the therapeutic dosing, tumor reduction efficacy, and selective distribution of Pt-Mal-LHRH in-vivo.

Methods and results

LHRH tissue expression levels in-vivo were investigated using western blotting and LHRH was found to be increased in reproductive tissues (mammary, ovary, uterus). Further, Pt-Mal-LHRH was found to have increased TNBC tumor tissue platinum accumulation compared to carboplatin by inductively coupled plasma mass spectrometry analysis. The platinum family, compound carboplatin, was selected for comparison due

SUBMITTER: Ndinguri M 

PROVIDER: S-EPMC10564129 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature