Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model.

ABSTRACT:

Introduction

Volatile and intravenous anesthetics may worsen oncologic outcomes in basic science animal models. These effects may be related to suppressed innate and adaptive immunity, decreased immunosurveillance, and disrupted cellular signaling. We hypothesized that anesthetics would promote lung tumor growth via altered immune function in a murine model and tested this using an immunological control group of immunodeficient mice.

Methods

Lewis lung carcinoma cells were injected via tail vein into C57BL/6 immunocompetent and NSG immunodeficient mice during exposure to isoflurane and ketamine versus controls without anesthesia. Mice were imaged on days 0, 3, 10, and 14 post-tumor cell injection. On day 14, mice were euthanized and organs fixed for metastasis quantification

SUBMITTER: Abrahams D 

PROVIDER: S-EPMC10564181 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature