An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8⁺ T cell magnitude and short-lived differentiation status.

ABSTRACT: Before initiation of antiretroviral therapy (ART), HIV-specific CD8⁺ T cells are dysfunctional and short lived. To better understand the relationship between the HIV reservoir in CD4⁺ T cells and the magnitude and differentiation status of HIV-specific CD8⁺ T cells, we investigated these cells from acute and chronic HIV-infected individuals after 2 years of ART. Although both the HIV reservoir and the CD8⁺ T cell responses declined significantly after 2 years of ART, sustained HIV-specific CD8⁺ T cell responses correlated with a greater reduction of integrated HIV provirus. However, the magnitude of CD8⁺ T cells specific for HIV Gag, Pol, Nef, and Vif proteins positively associated with the active reservoir size during ART,

SUBMITTER: Takata H 

PROVIDER: S-EPMC10564289 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature