Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis.

ABSTRACT:

Background

Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF.

Methods

Infants with CF were enrolled before 4 months of age. Multiplex PCR assays were performed on nasal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent CT imaging at approximately 12 months of age. Associations between Perth-Rotterdam Annotated Grid Morphometric Analysis for CF (PRAGMA-CF) CT scores and respiratory viruses and symptoms were assessed with Spearman correlation coefficients.

Result

SUBMITTER: Sanders DB 

PROVIDER: S-EPMC10564322 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature