Discrepancies between Cystatin C-Based and Creatinine-Based eGFR.

ABSTRACT:

Background

Recent guidance suggests clinicians increase use of cystatin C for the estimation of GFR. Discrepant levels of creatinine- versus cystatin C-based eGFR (eGFRcr versus eGFRcys) can occur and might signify inaccurate estimation of GFR using creatinine alone. This study sought to enhance the knowledge of the risk factors and clinical implications of having a large eGFR discrepancy.

Methods

Participants in the Atherosclerosis Risk in Communities Study, a prospective cohort study of US adults, were followed over 25 years. eGFR discrepancy was measured at five clinical visits and defined as eGFRcys either 30% lower or higher than eGFRcr, the current clinical standard of care. The associations between eGFR discrepancies and kidney-related laboratory parameters were asses

SUBMITTER: Farrington DK 

PROVIDER: S-EPMC10564370 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature