Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness.

ABSTRACT:

Background

Incomplete recovery of kidney function is an important adverse outcome in survivors of critical illness. However, unlike eGFR creatinine, eGFR cystatin C is not confounded by muscle loss and may improve identification of persistent kidney dysfunction.

Methods

To assess kidney function during prolonged critical illness, we enrolled 38 mechanically ventilated patients with an expected length of stay of >72 hours near admission to intensive care unit (ICU) in a single academic medical center. We assessed sequential kidney function using creatinine, cystatin C, and iohexol clearance measurements. The primary outcome was difference between eGFR creatinine and eGFR cystatin C at ICU discharge using Bayesian regression modeling. We simultaneously measured muscle mass by

SUBMITTER: Haines RW 

PROVIDER: S-EPMC10564373 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature