Prolonged antibiotic prophylaxis after pancreatoduodenectomy: systematic review and meta-analysis.

ABSTRACT:

Background

Previous studies have reported conflicting results of prolonged antibiotic prophylaxis on infectious complications after pancreatoduodenectomy. This study evaluated the effect of prolonged antibiotics on surgical-site infections (SSIs) after pancreatoduodenectomy.

Methods

A systematic review and meta-analysis was undertaken of SSIs in patients with perioperative (within 24 h) versus prolonged antibiotic (over 24 h) prophylaxis after pancreatoduodenectomy. SSIs were classified as organ/space infections or superficial SSI within 30 days after surgery. ORs were calculated using a Mantel-Haenszel fixed-effect model.

Results

Ten studies were included in the qualitative analysis, of which 8 reporting on 1170 patients were included in the quantitative analysis. Th

SUBMITTER: Droogh DHM 

PROVIDER: S-EPMC10564402 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature