Screening diagnostic markers of osteoporosis based on ferroptosis of osteoblast and osteoclast.

ABSTRACT:

Background

Osteoporosis is a negative balance of bone metabolism caused by the lower bone formation of osteoblasts than the bone absorption of osteoclasts. Ferroptosis plays an important role in osteoporosis, but its effects on osteoblasts and osteoclasts are still unclear.

Methods

First, we compared the osteogenic differentiation potential of MSCs and osteoclast differentiation potential of monocytes between osteoporosis mice and control. Then, we obtained gene expression profiles of MSCs and monocytes, and screened differentially expressed genes for enrichment analysis. Next, we cluster the patients with osteoporosis according to genes related to osteogenesis inhibition and osteoclast promotion. Finally, according to the expression of different subtypes of ferroptosis gene

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10564410 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature