Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study.

ABSTRACT:

Background

Pathways explaining racial/ethnic disparities in dementia risk are under-evaluated.

Methods

We examine those disparities and their related pathways among UK Biobank study respondents (50-74 y, N = 323,483; 3.6% non-White minorities) using a series of Cox proportional hazards and generalized structural equations models (GSEM).

Results

After ≤15 years, 5,491 all-cause dementia cases were diagnosed. Racial minority status (RACE_ETHN, Non-White vs. White) increased dementia risk by 24% (HR = 1.24, 95% CI: 1.07-1.45, P = 0.005), an association attenuated by socio-economic status (SES), (HR = 1.12, 95% CI: 0.96-1.31). Total race-dementia effect was mediated through both SES and Life's Essential 8 lifestyle sub-score (LE8_LIFESTYLE), combin

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC10564412 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature