Prognostic significance of CTNNB1 mutation in hepatocellular carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Backgrounds

Hepatocellular Carcinoma (HCC) is one of the most common malignant cancers in humans and has a high fatality rate. In recent years, researchers have verified that the Wnt/β-catenin signaling pathway affects the clinicopathological features and prognosis of patients with HCC. Although many studies have investigated the relationship between Wnt/β-catenin signaling pathway and HCC, the prognostic value of β-catenin in HCC remains inconclusive. CTNNB1 (Catenin Beta-1) is an important factor in the Wnt/β-catenin signaling pathway. However, no consensus has been reached on the clinical and prognostic significance of CTNNB1 mutations in HCCs.

Methods

Eligible studies and relevant data were obtained from PubMed, Web of Science, Elsevier, Cochrane Library, O

SUBMITTER: Lu G 

PROVIDER: S-EPMC10564414 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature