M5C methylation modification guides the prognostic value and immune landscapes in acute myeloid leukemia.

ABSTRACT: The development, incidence, and metastasis of tumors are all intimately correlated with 5-methylcytosine (m5C). However, uncertainty surrounds the function of m5C in acute myeloid leukemia (AML). In this study, multicenter AML data were collected and analyzed comprehensively to grasp the gene expression level, clinicopathological characteristics, prognostic significance of m5C in AML and its relationship with the tumor microenvironment (TME). The m5C gene-mediated scoring system (m5CSS) was created using principal component analysis, and multiple cox regression analyses were utilized to determine the prognostic relevance of the m5C score. The investigation of the correlation among m5C, immune characteristics, clinical characteristics, immune infiltration level, as well as drug reaction at

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10564437 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature