Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models.

ABSTRACT: Metabolic capacity can vary substantially within a bacterial species, leading to ecological niche separation, as well as differences in virulence and antimicrobial susceptibility. Genome-scale metabolic models are useful tools for studying the metabolic potential of individuals, and with the rapid expansion of genomic sequencing there is a wealth of data that can be leveraged for comparative analysis. However, there exist few tools to construct strain-specific metabolic models at scale. Here, we describe Bactabolize, a reference-based tool which rapidly produces strain-specific metabolic models and growth phenotype predictions. We describe a pan reference model for the priority antimicrobial-resistant pathogen, Klebsiella pneumoniae, and a quality control framework for using draft g

SUBMITTER: Vezina B 

PROVIDER: S-EPMC10564454 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature