Unaltered hepatic wound healing response in male rats with ancestral liver injury.

ABSTRACT: The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of transgenerational responses to various environmental factors have been published but due to technical, operational and resource burden, most still await independent confirmation. A previous study reported multigenerational epigenetic adaptation of the hepatic wound healing response upon exposure to the hepatotoxicant carbon tetrachloride (CCl₄) in male rats. Here, we comprehensively investigate the transgenerational effects by repeating the original CCl₄ multigenerational study with increased power, pedigree tracing, F2 dose-response and suitable randomization schemes. Detailed pathology evaluations do not support

SUBMITTER: Beil J 

PROVIDER: S-EPMC10564731 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature