FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.

ABSTRACT: Cold stimulation dynamically remodels mitochondria in brown adipose tissue (BAT) to facilitate non-shivering thermogenesis in mammals, but what regulates mitochondrial plasticity is poorly understood. Comparing mitochondrial proteomes in response to cold revealed FAM210A as a cold-inducible mitochondrial inner membrane protein. An adipocyte-specific constitutive knockout of Fam210a (Fam210a^AKO) disrupts mitochondrial cristae structure and diminishes the thermogenic activity of BAT, rendering the Fam210a^AKO mice vulnerable to lethal hypothermia under acute cold exposure. Induced knockout of Fam210a in adult adipocytes (Fam210a^iAKO) does not affect steady-state mitochondrial structure under thermoneutrality, but impairs cold-induced mitochondrial remodeling,

SUBMITTER: Qiu J 

PROVIDER: S-EPMC10564795 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature