Use of patient-derived explants as a preclinical model for precision medicine in colorectal cancer: A scoping review.

ABSTRACT:

Purpose

Whilst the treatment paradigm for colorectal cancer has evolved significantly over time, there is still a lack of reliable biomarkers of treatment response. Treatment decisions are based on high-risk features such as advanced TNM stage and histology. The role of the tumour microenvironment, which can influence tumour progression and treatment response, has generated considerable interest. Patient-derived explant cultures allow preservation of native tissue architecture and tumour microenvironment. The aim of the scoping review is to evaluate the utility of patient-derived explant cultures as a preclinical model in colorectal cancer.

Methods

A search was conducted using Ovid MEDLINE, EMBASE, Web of Science, and Cochrane databases from start of database records to Sept

SUBMITTER: Mui M 

PROVIDER: S-EPMC10564805 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature