Treatment of Lp(a): Is It the Future or Are We Ready Today?

ABSTRACT:

Purpose of review

The goal of this review is to present the pharmacodynamic effectiveness as well as the clinical efficacy and safety of investigational antisense oligonucleotides (ASOs) and small interference RNAs (siRNAs) drugs that specifically target lipoprotein(a) (Lp(a)). The review will discuss whether the existing lipid-lowering therapies are adequate to treat high Lp(a) levels or whether it is necessary to use the emerging new therapeutic approaches which are based on the current RNA technologies.

Recent findings

Lipoprotein(a) (Lp(a)) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD), independent of other conventional risk factors. High Lp(a) levels are also independently associated with an increased risk of aortic stenosis progression rate

SUBMITTER: Tselepis AD 

PROVIDER: S-EPMC10564831 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature