The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains.

ABSTRACT: Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in the brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers and plaques. Macroautophagy, a form of autophagy characterized by a double-membrane vesicle, plays a crucial role in maintaining neuronal homeostasis by degrading protein aggregates and dysfunctional organelles as a quality control process. Recently, DEF8, a relatively uncharacterized protein, has been proposed as a participant in vesicular traffic and autophagy pathways. We have reported increased DEF8 levels in lymphocytes from mild cognitive impairment (MCI) and early-stage AD patients and a neuronal profile in a murine transgenic AD model. Here, we analyzed DEF8 l

SUBMITTER: Oyarce-Pezoa S 

PROVIDER: S-EPMC10564863 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature