Catheter-associated Mycobacterium intracellulare biofilm infection in C3HeB/FeJ mice.

ABSTRACT: Non-tuberculosis mycobacterial (NTM) diseases are steadily increasing in prevalence and mortality worldwide. Mycobacterium avium and M. intracellulare, the two major pathogens of NTM diseases, are resistant to antibiotics, and chlorine, necessitating their capacity to survive in natural environments (e.g. soil and rivers) and disinfected municipal water. They can also form biofilms on artificial surfaces to provide a protective barrier and habitat for bacilli, which can cause refractory systemic disseminated NTM disease. Therefore, preventing biofilm formation by these pathogens is crucial; however, not many in vivo experimental systems and studies on NTM biofilm infection are available. This study develops a mouse model of catheter-associated systemic disseminated disease caused by M. int

SUBMITTER: Yamamoto K 

PROVIDER: S-EPMC10564925 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature