Mean Arterial Pressure and Cerebral Hemodynamics Across The Lifespan: A Cross-Sectional Study From Human Connectome Project-Aging.

ABSTRACT:

Background

Cerebral perfusion is directly affected by systemic blood pressure, which has been shown to be negatively correlated with cerebral blood flow (CBF). The impact of aging on these effects is not fully understood.

Purpose

To determine whether the relationship between mean arterial pressure (MAP) and cerebral hemodynamics persists throughout the lifespan.

Study type

Retrospective, cross-sectional study.

Population

Six hundred and sixty-nine participants from the Human Connectome Project-Aging ranging between 36 and 100+ years and without a major neurological disorder.

Field strength/sequence

Imaging data was acquired at 3.0 Tesla using a 32-channel head coil. CBF and arterial transit time (ATT) were measured by multi-delay pseudo-continuous arteri

SUBMITTER: Yetim E 

PROVIDER: S-EPMC10564963 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature