Words hurt: common and distinct neural substrates underlying nociceptive and semantic pain.

ABSTRACT:

Introduction

Recent studies have shown that processing semantic pain, such as words associated with physical pain, modulates pain perception and enhances activity in regions of the pain matrix. A direct comparison between activations due to noxious stimulation and processing of words conveying physical pain may clarify whether and to what extent the neural substrates of nociceptive pain are shared by semantic pain. Pain is triggered also by experiences of social exclusion, rejection or loss of significant others (the so-called social pain), therefore words expressing social pain may modulate pain perception similarly to what happens with words associated with physical pain. This event-related fMRI study aims to compare the brain activity related to perceiving nociceptive pain and t

SUBMITTER: Borelli E 

PROVIDER: S-EPMC10565001 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature