Case report: Serious unexpected vascular events in two patients with lymphocytic variant hypereosinophilic syndrome.

ABSTRACT:

Background

Lymphocytic-variant hypereosinophilic syndrome (L-HES) is a form of reactive hypereosinophilia, most commonly associated with interleukin-5 over-production by clonal, most commonly CD3^-CD4⁺CD2^hiCD5^hiCD45RO⁺ T-cells. Patients often present with predominant cutaneous and soft-tissue manifestations, while cardiovascular involvement is uncommon.

Methods

We reviewed the medical files of two L-HES patients followed in our center who developed serious vascular complications and performed a literature review for similar cases.

Results

Patient 1, a 52-year-old female, presented with an ischemic stroke secondary to left middle cerebral artery dissection after 10 years of indolent L-HES. Blood eosinophilia was con

SUBMITTER: Nathan T 

PROVIDER: S-EPMC10565030 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature