Modulation of associations between education years and cortical volume in Alzheimer's disease vulnerable brain regions by Aβ deposition and APOE ε4 carrier status in cognitively normal older adults.

ABSTRACT:

Background

Education years, as a measure of cognitive reserve, have been shown to affect the progression of Alzheimer's disease (AD), both pathologically and clinically. However, inconsistent results have been reported regarding the association between years of education and intermediate structural changes in AD-vulnerable brain regions, particularly when AD risk factors were not considered during the preclinical phase.

Objective

This study aimed to examine how Aβ deposition and APOE ε4 carrier status moderate the relationship between years of education and cortical volume in AD-vulnerable regions among cognitively normal older adults.

Methods

A total of 121 participants underwent structural MRI, [¹⁸F] flutemetamol PET-CT imaging, and neuropsychologi

SUBMITTER: Kim HB 

PROVIDER: S-EPMC10565031 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature