Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants.

ABSTRACT: Transporting epithelia provide a protective barrier against pathogenic insults while allowing the controlled exchange of ions, solutes and water with the external environment. In invertebrates, these functions depend on formation and maintenance of 'tight' septate junctions (SJs). However, the mechanism by which SJs affect transport competence and tissue homeostasis, and how these are modulated by ageing, remain incompletely understood. Here, we demonstrate that the Drosophila renal (Malpighian) tubules undergo an age-dependent decline in secretory capacity, which correlates with mislocalisation of SJ proteins and progressive degeneration in cellular morphology and tissue homeostasis. Acute loss of the SJ protein Snakeskin in adult tubules induced progressive changes in cellular and tissue

SUBMITTER: Dornan AJ 

PROVIDER: S-EPMC10565245 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature