Serum and urine metabolomic biomarkers for predicting prognosis in patients with immunoglobulin A nephropathy.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is the most prevalent form of glomerulonephritis worldwide. Prediction of disease progression in IgAN can help to provide individualized treatment based on accurate risk stratification.

Methods

We performed proton nuclear magnetic resonance-based metabolomics analyses of serum and urine samples from healthy controls, non-progressor (NP), and progressor (P) groups to identify metabolic profiles of IgAN disease progression. Metabolites that were significantly different between the NP and P groups were selected for pathway analysis. Subsequently, we analyzed multivariate area under the receiver operating characteristic (ROC) curves to evaluate the predictive power of metabolites associated with IgAN progression.

Results

We o

SUBMITTER: Jeon YH 

PROVIDER: S-EPMC10565460 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature