Divergent molecular events underlying initial T-cell commitment in human prenatal and postnatal thymus.

ABSTRACT:

Introduction

Intrathymic T-cell development is a coordinated process accompanied by dynamic changes in gene expression. Although the transcriptome characteristics of developing T cells in both human fetal and postnatal thymus at single-cell resolution have been revealed recently, the differences between human prenatal and postnatal thymocytes regarding the ontogeny and early events of T-cell development still remain obscure. Moreover, the transcriptional heterogeneity and posttranscriptional gene expression regulation such as alternative polyadenylation at different stages are also unknown.

Method

In this study, we performed integrative single-cell analyses of thymocytes at distinct developmental stages.

Results

The subsets of prenatal CD4^-CD8^- d

SUBMITTER: He H 

PROVIDER: S-EPMC10565475 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature