Sterile triggers drive joint inflammation in TNF- and IL-1β-dependent mouse arthritis models.

ABSTRACT: Arthritis is the most common extra-intestinal complication in inflammatory bowel disease (IBD). Conversely, arthritis patients are at risk for developing IBD and often display subclinical gut inflammation. These observations suggest a shared disease etiology, commonly termed "the gut-joint-axis." The clinical association between gut and joint inflammation is further supported by the success of common therapeutic strategies and microbiota dysbiosis in both conditions. Most data, however, support a correlative relationship between gut and joint inflammation, while causative evidence is lacking. Using two independent transgenic mouse arthritis models, either TNF- or IL-1β dependent, we demonstrate that arthritis develops independently of the microbiota and intestinal inflammation, since both

SUBMITTER: Thiran A 

PROVIDER: S-EPMC10565626 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature