Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine.

ABSTRACT: Human papillomavirus (HPV) infections are the cause of all cervical and numerous oropharyngeal and anogenital cancers. The currently available HPV vaccines, which induce neutralizing antibodies, have no therapeutic effect on established tumors. Here, we developed an immuno-oncotherapy against HPV-induced tumors based on a non-integrative lentiviral vector encoding detoxified forms of the Early E6 and E7 oncoproteins of HPV16 and 18 genotypes, namely, "Lenti-HPV-07". A single intramuscular injection of Lenti-HPV-07 into mice bearing established HPV-induced tumors resulted in complete tumor eradication in 100% of the animals and was also effective against lung metastases. This effect correlated with CD8⁺ T-cell induction and profound remodeling of the tumor microenvironment. In th

SUBMITTER: Douguet L 

PROVIDER: S-EPMC10565635 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature