Single-cell profiling of muscle-infiltrating T cells in idiopathic inflammatory myopathies.

ABSTRACT: Idiopathic inflammatory myopathies (IIM) are rare autoimmune systemic diseases characterized by muscle weakness and the presence of muscle-infiltrating T cells. IIM represent a clinical challenge due to heterogeneity of symptoms and variability of response to immunosuppressive treatment. Here, we performed in-depth single-cell sequencing on muscle-infiltrating T cells and peripheral blood memory T cells in six patients with recently diagnosed IIM. We identified tissue resident memory T-cell (T_RM ) signatures including the expression of HOBIT, XCL1 and CXCR6 in the muscle biopsies of all patients with IIM. Clonally expanded T-cell clones were mainly found among cytotoxic and T_RM implying their role in the disease pathogenesis. Finally, identical expanded T-cell clones

SUBMITTER: Argyriou A 

PROVIDER: S-EPMC10565639 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature