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SOHO State of the Art Updates and Next Questions | New Pathways and New Targets in PTCL: Staying on Target.

ABSTRACT: While the peripheral T-cell lymphomas (PTCL) remain a therapeutic challenge, and increasingly account for a disproportionate number of lymphoma-related deaths, improved understanding of disease pathogenesis and classification, and the development of novel therapeutic agents over the past decade, all provide reasons for a more optimistic outlook in the next. Despite their genetic and molecular heterogeneity, many PTCL are dependent upon signaling input provided by antigen, costimulatory, and cytokine receptors. While gain-of-function alterations effecting these pathways are recurrently observed in many PTCL, more often than not, signaling remains ligand-and tumor microenvironment (TME)-dependent. Consequently, the TME and its constituents are increasingly recognized as "on target". Utilizing a "3 signal" model, we will review new-and old-therapeutic targets that are relevant for the more common nodal PTCL subtypes.

SUBMITTER: Carty SA

PROVIDER: S-EPMC10565700 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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SOHO State of the Art Updates and Next Questions | New Pathways and New Targets in PTCL: Staying on Target.

Carty Shannon A SA Murga-Zamalloa Carlos A CA Wilcox Ryan A RA

Clinical lymphoma, myeloma & leukemia 20230419 8

While the peripheral T-cell lymphomas (PTCL) remain a therapeutic challenge, and increasingly account for a disproportionate number of lymphoma-related deaths, improved understanding of disease pathogenesis and classification, and the development of novel therapeutic agents over the past decade, all provide reasons for a more optimistic outlook in the next. Despite their genetic and molecular heterogeneity, many PTCL are dependent upon signaling input provided by antigen, costimulatory, and cyto ...[more]

PMID: 37142534

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