Effect of Porous Substrate Topographies on Cell Dynamics: A Computational Study.

ABSTRACT: Controlling cell-substrate interactions via the microstructural characteristics of biomaterials offers an advantageous path for modulating cell dynamics, mechanosensing, and migration, as well as for designing immune-modulating implants, all without the drawbacks of chemical-based triggers. Specifically, recent in vivo studies have suggested that a porous implant's microscale curvature landscape can significantly impact cell behavior and ultimately the immune response. To investigate such cell-substrate interactions, we utilized a 3D computational model incorporating the minimum necessary physics of cell migration and cell-substrate interactions needed to replicate known in vitro behaviors. This model specifically incorporates the effect of membrane tension, which was found t

SUBMITTER: Gonthier AR 

PROVIDER: S-EPMC10565724 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature