Peptide-Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes.

ABSTRACT: Multicomponent self-assembly offers opportunities for the design of complex and functional biomaterials with tunable properties. Here, we demonstrate how minor modifications in the molecular structures of peptide amphiphiles (PAs) and elastin-like recombinamers (ELs) can be used to generate coassembling tubular membranes with distinct structures, properties, and bioactivity. First, by introducing minor modifications in the charge density of PA molecules (PAK2, PAK3, PAK4), different diffusion-reaction processes can be triggered, resulting in distinct membrane microstructures. Second, by combining different types of these PAs prior to their coassembly with ELs, further modifications can be achieved, tuning the structures and properties of the tubular membranes. Finally, by introducing the c

SUBMITTER: Majkowska A 

PROVIDER: S-EPMC10565817 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature