A pilot study: handgrip as a predictor in the disease progression of SCA3.

ABSTRACT:

Background

Spinocerebellar ataxia type 3 (SCA3) is an inherited, autosomal, and rare neurodegenerative disease. Serum/plasma biomarkers or functional magnetic resonance imaging used to assess progression, except for neurological examinations, is either inconvenient or expensive. Handgrip strength (HGS) may be considered as a biomarker to predict the progress of SCA3 and align with the alteration of plasma neurofilament light chain (NfL) and Scale for the Assessment and Rating of Ataxia (SARA).

Methods

Patients with SCA3 and healthy subjects were recruited from Changhua Christian Hospital. SARA, body mass index (BMI), and NfL were obtained for both groups. HGS was measured using a Jamar Plus + hand dynamometer.

Results

This study recruited 31 patients and 36 controls.

SUBMITTER: Chiu C 

PROVIDER: S-EPMC10565987 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature