Bronchial epithelial gene expression and interstitial lung abnormalities.

ABSTRACT:

Introduction

Interstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In particular, the fibrotic subtype of ILA is associated with increased mortality and rapid decline in lung function. Understanding the differential gene expression that occurs in the lungs of participants with fibrotic ILA may provide insight into development of a useful biomarker for early detection and therapeutic targets for progressive pulmonary fibrosis.

Methods

Measures of ILA and gene expression data were available in 213 participants in the Detection of Early Lung Cancer Among Military Personnel (DECAMP1 and DECAMP2) cohorts. ILA was defined using Fleischner Society guidelines and determined by sequential reading of computed to

SUBMITTER: Menon AA 

PROVIDER: S-EPMC10566143 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature