Giardia VSPAS7 protein attenuates Giardia intestinalis-induced host macrophage pyroptosis.

ABSTRACT:

Background

The unicellular protozoan parasite Giardia intestinalis, which primarily infects humans and animals such as cattle and sheep, is having a major negative impact on public health. Giardia is able to evade the recognition and elimination of the host immune system because of the trophozoite surface and extracellular vesicles (EVs) covered by variant-specific surface proteins (VSPs). As key proteins for immune evasion, whether VSPs can regulate Giardia-induced pyroptosis and promote Giardia evasion of host immune responses has not been reported.

Methods

To examine the role of Giardia VSPAS7 on Giardia-induced activation of the signaling pathway, secretion of pro-inflammatory cytokines, pyroptosis and the mechanism involved, we constructed the pcDNA3.1-vspas7 expression

SUBMITTER: Sun M 

PROVIDER: S-EPMC10566177 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature