Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study.

ABSTRACT:

Background

The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationship between IBD and extracolonic cancers.

Methods

Independent genetic variants strongly associated with IBD were extracted as instrumental variables from genome-wide association study (GWAS) conducted by the International IBD Genetics Consortium including 12,882 IBD patients, 5956 Crohn's disease (CD) patients, and 6968 ulcerative colitis (UC) patients. Three sources of cancer GWAS were selected as outcome data. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of IBD on 32 extracolonic cancers. The meta-analysis was ap

SUBMITTER: Gao H 

PROVIDER: S-EPMC10566178 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature