Dynamic Evolution of Bacterial Ligand Recognition by Formyl Peptide Receptors.

ABSTRACT: The detection of invasive pathogens is critical for host immune defense. Cell surface receptors play a key role in the recognition of diverse microbe-associated molecules, triggering leukocyte recruitment, phagocytosis, release of antimicrobial compounds, and cytokine production. The intense evolutionary forces acting on innate immune receptor genes have contributed to their rapid diversification across plants and animals. However, the functional consequences of immune receptor divergence are often unclear. Formyl peptide receptors (FPRs) comprise a family of animal G protein-coupled receptors which are activated in response to a variety of ligands including formylated bacterial peptides, pathogen virulence factors, and host-derived antimicrobial peptides. FPR activation in turn promotes i

SUBMITTER: Paterson NM 

PROVIDER: S-EPMC10566242 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature