Suspect screening of exogenous compounds using multiple reaction screening (MRM) profiling in human urine samples.

ABSTRACT: Thousands of chemical compounds produced by industry are dispersed in the human environment widely enough to reach the world population, and the introduction of new chemicals constantly occurs. As new synthetic molecules emerge, rapid analytical workflows for screening possible presence of exogenous compounds in biofluids can be useful as a first pass analysis to detect chemical exposure and guide the development and application of more elaborate LC-MS/MS methods for quantification. In this study, a suspect screening workflow using the multiple reaction monitoring (MRM) profiling method is proposed as a first pass exploratory technique to survey selected exogenous molecules in human urine samples. The workflow was applied to investigate 12 human urine samples using 310 MRMs related to the

SUBMITTER: Marasco Junior CA 

PROVIDER: S-EPMC10566365 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature