Clinical efficacy of plasma exchange in systemic lupus erythematosus during pregnancy.

ABSTRACT:

Objective

To investigate the clinical efficacy of plasma exchange (PE) with or without prednisone and hydroxychloroquine (HCQ) for the treatment of systemic lupus erythematosus (SLE) during pregnancy.

Methods

The clinical characteristics of 14 pregnant women with SLE admitted to our hospital were retrospectively analyzed, including 7 only treated with prednisone and HCQ (non-PE group) as well as 7 combined PE (PE group). The delivery situations of 14 patients were recorded. Data like erythrocyte sedimentation rate (ESR), urine protein, platelet count, and SLEDAI scores were compared between two groups before treatment and 3, 6, and 12 months after delivery.

Results

Three patients in the non-PE group ended in miscarriage while all patients in the PE group were delivere

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10566447 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature