Genomic Characterization of 2 Cutibacterium acnes Isolates from a Surgical Site Infection Reveals Large Genomic Inversion.

ABSTRACT:

Background

Cutibacterium acnes is a common commensal of human skin but may also present as an opportunistic pathogen in prosthetic joint and wound infections. Unfortunately, few complete genomes of C. acnes are publicly available, and even fewer are of isolates associated with infection. Here we report the isolation, characterization, and complete genomes of 2 C. acnes isolates from a surgical site infection of an elbow.

Methods

We used standard microbiological methods for phenotypic characterization and performed whole genome sequencing on 2 C. acnes isolates using a combination of short-read and long-read sequencing.

Results

Antibiotic susceptibility testing showed beta-lactamase negative and low minimal inhibitory concentrations to all a

SUBMITTER: Brown DG 

PROVIDER: S-EPMC10566467 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature