Robotically Embodied Biological Neural Networks to Investigate Haptic Restoration with Neuroprosthetic Hands.

ABSTRACT: Neuroprosthetic limbs reconnect severed neural pathways for control of (and increasingly sensation from) an artificial limb. However, the plastic interaction between robotic and biological components is poorly understood. To gain such insight, we developed a novel noninvasive neuroprosthetic research platform that enables bidirectional electrical communications (action, sensory perception) between a dexterous artificial hand and neuronal cultures living in a multichannel microelectrode array (MEA) chamber. Artificial tactile sensations from robotic fingertips were encoded to mimic slowly adapting (SA) or rapidly adapting (RA) mechanoreceptors. Afferent spike trains were used to stimulate neurons in a region of the neuronal culture. Electrical activity from neurons at another region in the

SUBMITTER: Ades C 

PROVIDER: S-EPMC10566548 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature