Airway microbiota and immune mediator relationships differ in obesity and asthma.

ABSTRACT:

Background

Asthma and obesity are both complex conditions characterized by chronic inflammation, and obesity-related severe asthma has been associated with differences in the microbiome. However, whether the airway microbiome and microbiota-immune response relationships differ between obese persons with or without nonsevere asthma is unestablished.

Objective

We compared the airway microbiome and microbiota-immune mediator relationships between obese and nonobese subjects, with and without mild-moderate asthma.

Methods

We performed cross-sectional analyses of the airway (induced sputum) microbiome and cytokine profiles from blood and sputum using 16S ribosomal RNA gene and internal transcribed spacer region sequencing to profile bacteria and fungi, and multiplex immuno

SUBMITTER: Kozik AJ 

PROVIDER: S-EPMC10566565 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature