Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology.

ABSTRACT: Evidence suggests that innate and adaptive cellular responses mediate resistance to the influenza virus and confer protection after vaccination. However, few studies have resolved the contribution of cellular responses within the context of preexisting antibody titers. Here, we measured the peripheral immune profiles of 206 vaccinated or unvaccinated adults to determine how baseline variations in the cellular and humoral immune compartments contribute independently or synergistically to the risk of developing symptomatic influenza. Protection correlated with diverse and polyfunctional CD4⁺ and CD8⁺ T, circulating T follicular helper, T helper type 17, myeloid dendritic and CD16⁺ natural killer (NK) cell subsets. Conversely, increased susceptibility was pred

SUBMITTER: Mettelman RC 

PROVIDER: S-EPMC10566627 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature