Transcription factor competition facilitates self-sustained oscillations in single gene genetic circuits.

ABSTRACT: Genetic feedback loops can be used by cells to regulate internal processes or to keep track of time. It is often thought that, for a genetic circuit to display self-sustained oscillations, a degree of cooperativity is needed in the binding and unbinding of actor species. This cooperativity is usually modeled using a Hill function, regardless of the actual promoter architecture. Furthermore, genetic circuits do not operate in isolation and often transcription factors are shared between different promoters. In this work we show how mathematical modelling of genetic feedback loops can be facilitated with a mechanistic fold-change function that takes into account the titration effect caused by competing binding sites for transcription factors. The model shows how the titration effect facilitat

SUBMITTER: Landman J 

PROVIDER: S-EPMC10566692 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature