Large-scale plasma proteomics comparisons through genetics and disease associations.

ABSTRACT: High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge the gap between the genome and diseases. Here we performed association studies of Olink Explore 3072 data generated by the UK Biobank Pharma Proteomics Project¹ on plasma samples from more than 50,000 UK Biobank participants with phenotypic and genotypic data, stratifying on British or Irish, African and South Asian ancestries. We compared the results with those of a SomaScan v4 study on plasma from 36,000 Icelandic people², for 1,514 of whom Olink data were also available. We found modest correlation between the two platforms. Although cis protein quantitative trait loci were detected for a similar absolute number of

SUBMITTER: Eldjarn GH 

PROVIDER: S-EPMC10567571 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature