Clinical utility of C-reactive protein-based triage for presumptive pulmonary tuberculosis in South African adults.

ABSTRACT:

Background

Identification of an accurate, low-cost triage test for pulmonary TB among people presenting to healthcare facilities is an urgent global research priority. We assessed the diagnostic accuracy and clinical utility of C-reactive protein (CRP) for TB triage among symptomatic adult outpatients, irrespective of HIV status.

Methods

We prospectively enrolled adults reporting at least one (for people with HIV) or two (for people without HIV) symptoms of cough, fever, night sweats, or weight loss at two TB clinics in Cape Town, South Africa. Participants provided sputum for culture and Xpert MTB/RIF Ultra. We evaluated the diagnostic accuracy of CRP (measured using a laboratory-based assay) against a TB-culture reference standard as the area under the receiver operating c

SUBMITTER: Calderwood CJ 

PROVIDER: S-EPMC10567578 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature